Department of Biochemistry, University of Oxford, South Parks Rd, Oxford. OX1 3QU

COSMIC - Publications

List of publications containing data produced at COSMIC

Hall PR, Jouen-Tachoire T, Schewe M, et al. 2025. Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease. Structure doi:10.1038/s41594-020-0507-4

Rödström KEJ, Eymsh B, Proks P, et al. 2025. Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics. Nat Struct Mol Biol doi: 10.1038/s41594-025-01497-6

Chen Z, Chi G, Balo T, et al. 2025. Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment. Nat Commun  doi: 10.1038/s41467-025-58350-z

Karabova MK, del Ser-Badia A, Hedegaard A, et al. 2025. Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles. BioRXiv doi:10.1101/2025.07.17.664991

Li A, Webster R, Maxwell S, et al. 2025. Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states. Cell Rep doi:10.1016/j.celrep.2025.115581

Farrell B, Alam N, Hart MN, et al. 2024. The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature doi:10.1038/s41586-023-06856-1

Gérard SF, Redfield C, Higgins MK. 2024. Structural basis for carbohydrate recognition by the Gal/GalNAc lectin of Entamoeba histolytica. BioRXiv doi:10.1101/2024.08.28.610168

Williams-Jones DP, Webby MN, Press CE, et al. 2023. Tunable force transduction through the Escherichia coli cell envelope. PNAS doi:10.1073/pnas.2306707120

Cook AD, Carrington M, Higgins MK. 2023. Molecular mechanism of complement inhibition by the trypanosome receptor ISG65. eLife  doi.org/10.7554/eLife.88960.2.

Esser TK, Böhning J, Fremdling P, et al. 2022. Mass-selective and ice-free electron cryomicroscopy protein sample preparation via native electrospray ion-beam deposition. PNAS doi:10.1093/pnasnexus/pgac153

Silvester E, Vollmer B, Pražák V, et al. 2021. DNA origami signposts for identifying proteins on cell membranes by electron cryotomography. Cell  doi:10.1016/j.cell.2021.01.033

Housden NG, Webby MN, Lowe ED, et al. 2021. Toxin import through the antibiotic efflux channel TolC. Nat Commun doi:10.1038/s41467-021-24930-y

Francis MR, Webby MN, Housden NG, et al. 2021. Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. EMBO J doi:10.15252/embj.2021108610

Adams O, Deme JC, Parker JL, Fowler PW, Lea SM, Newstead S. 2021. Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target. Structure doi:10.1016/j.str.2021.06.013

Kuhlen L, Johnson S, Zeitler A, et al. 2020. The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion. Nat Commun doi:10.1038/s41467-020-15071-9

Johnson S, Fong YH, Deme JC, Furlong EJ, Kuhlen L, Lea SM. 2020. Symmetry mismatch in the MSring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nat Microbiol doi:10.1038/s41564-020-0703-3

von Kügelgen A, Tang H, Hardy GG, et al. 2020. In Situ Structure of an Intact LipopolysaccharideBound Bacterial Surface Layer. Cell  doi:10.1016/j.cell.2019.12.006

Gérard SF, Hall BS, Zaki AM, et al. 2020. Structure of the Inhibited State of the Sec Translocon. Mol Cell doi:10.1016/j.molcel.2020.06.013

Tarafder AK, von Kügelgen A, Mellul AJ, et al. 2020. Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped bacteria. PNAS doi:10.1073/pnas.1917726117

Lauber F, Deme JC, Lea SM, Berks BC. 2018. Type 9 secretion system structures reveal a new protein transport mechanism. Nature doi:10.1038/s41586-018-0693-y